Studies with human growth hormone.
نویسنده
چکیده
Let me tell you at the outset of my appreciation of the great honour you have done me in asking me to deliver the first Lawson Wilkins Memorial Lecture. I accepted this invitation with eagerness because I cherish any link that binds Lawson Wilkins' life and work to mine. I often turn to the page in the second edition of his great textbook in which he proudly listed the 31 Associates and Fellows who had worked with him from 1938 onwards. Between 1957 and his retirement other names were added to this published list. Nearly all ofthem are here this evening and all ofthem would have been here had it been possible. As I read these distinguished names, I recognize that it is in their achievement, present and promised, that Lawson Wilkins' true immortality lies. I count no man a great scientist who has not founded a school, who has not handed on his torch to a host of eager disciples. This was part of Rudyard Kipling's meaning when he wrote,
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In order to study the periplasmic expression of human growth hormone (hGH) in Escherichia coli, the related cDNA was inserted in two expression plasmids carrying pelB signal peptide, one with lac bacterial promoter and the other with a bacteriophage T7-based promoter. The recombinant plasmids were moved to TG1 and BL21 strains of E. coli, respectively. To induce the expression systems, IPTG and...
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Objective- To determine the effects of growth hormone (GH) therapy on bone density in controlled conditions in healthy adult rabbits. Design- Experimental in vivo study. Animal- 20 healthy, adult New Zealand White rabbits. Procedures- The rabbits were divided into 2 groups; receiving Human GH (0.006 mg/kg/d) and controls; receiving placebo for 3 months. The density of radius and tibia was m...
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ورودعنوان ژورنال:
- Archives of disease in childhood
دوره 41 215 شماره
صفحات -
تاریخ انتشار 1966